Cochrane corner: beta-blockers for hypertension
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Cochrane corner: beta-blockers for hypertension
BaCkground Beta-blockers refer to an assorted group of medications that block the action of endogenous catecholamines on beta-adrenergic receptors. The β1 and β2 receptors are the primary beta-adrenergic receptors in the human cardiovascular system. Betablockers differ in their β1/β2-receptor selectivity and vasodilatory properties. Based on this diversity, beta-blockers have been categorised i...
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BACKGROUND Beta-blockers refer to a mixed group of drugs with diverse pharmacodynamic and pharmacokinetic properties. They have shown long-term beneficial effects on mortality and cardiovascular disease (CVD) when used in people with heart failure or acute myocardial infarction. Beta-blockers were thought to have similar beneficial effects when used as first-line therapy for hypertension. Howev...
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Hypertension is a common condition in developed and developing nations, associated with cardiovascular complications and end organ damage, and yet its etiology remains largely elusive. It has long been recognized that satisfactory control of blood pressure reduces cardiovascular complications. Early trials, before the advent of drugs acting on the renin-aldosterone system, (RAS) revealed the th...
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ژورنال
عنوان ژورنال: Heart
سال: 2017
ISSN: 1355-6037,1468-201X
DOI: 10.1136/heartjnl-2017-311585